anders_CPH said:The mechanism is more central than most summaries suggest.
Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were relying on physical fullness feel the effect fade while the appetite effect is still working.
BariatricNurseD said:True, though the ladder is longer and that is not a neutral detail — six dose steps means six opportunities to stall on the way up, and plenty of…
This is exactly what I could not find anywhere else. Adding it to my notes with a link back to this thread.
anders_CPH said:The mechanism is more central than most summaries suggest.
I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.
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Browse GL BiochemOne concrete data point for the thread. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.
Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. No action needed from anybody.