From the other side of the consultation, briefly. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.
Correct me if the detail matters more than I have assumed.
Dr.GutHealth said:If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.
Thank you — that is the clearest version of this I have read, and I have read a lot of them. Taking it to my next appointment.
Adding the clinical framing, because it changes how the question reads. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.
Ask again with the specifics and you will get a better answer than this one.
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Browse GL BiochemGenomicsKate said:It helps to ask what evidence would change your mind before you look at any.
That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.
Ask again with the specifics and you will get a better answer than this one.
Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. No action needed from anybody.