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ForumsOral GLP-1 AgonistsOrforglipron Phase 2 weight loss data — what worked for you? Page 3

Orforglipron Phase 2 weight loss data — what worked for you?

NurseKim_ATL Thu, Jan 22, 2026 at 12:25 PM 13 replies 1,004 viewsPage 3 of 3
Dr.ObesityLA
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Jan 24, 2026 at 4:18 PM#11
Dr.EM_Chicago said:
Relative and absolute effects need reading together.

Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.

48 23zoe_NC, Dr.ObesityLA, NurseKim_ATL and 45 others
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marcus_mpls
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Jan 25, 2026 at 8:31 PM#12
KristenIndy said:
The manufacturing argument is the underrated one.

Saving this. It is the first explanation that did not require me to already understand it.

47 22oliver_london, tane_welly, Dr.PathRoch and 44 others
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JessicaM_2024
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Jan 27, 2026 at 12:43 AM#13
Dr.EM_Chicago said:
Relative and absolute effects need reading together.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.

Worth separating that from the trial evidence, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Last edited: Jan 27, 2026 at 1:43 AM
46 21mike_mealprep, NicoleRaleigh, james_edin and 43 others
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TrialTracker_MD
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Jan 28, 2026 at 4:55 AM#14

The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

Last edited: Jan 28, 2026 at 9:55 AM
45 20Dr.PulmRoch, maya_sedona, stefan_berlin and 42 others
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mike_mod
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Jan 29, 2026 at 9:06 AM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Report rather than reply if it drifts again.

44 19PurityPaulOR, MaxMetOK, MounjBrad and 41 others
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