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ForumsOral GLP-1 AgonistsCost comparison: oral vs injectable semaglutide — 12 month update Page 4

Cost comparison: oral vs injectable semaglutide — 12 month update

ben_calgary Mon, Oct 20, 2025 at 7:53 AM 23 replies 1,361 viewsPage 4 of 5
pat_auckland
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Oct 21, 2025 at 7:25 AM#16

Adding the clinical framing, because it changes how the question reads. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

43 18NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 40 others
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BethLabQueen
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Oct 21, 2025 at 10:33 AM#17

The figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

42 17Dr.PulmRoch, maya_sedona, stefan_berlin and 39 others
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cory_ATX
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Oct 21, 2025 at 1:41 PM#18

Following on from FDA_TrackerJim — and this may be the naive question:

How long did you give it before you decided it was working?

Last edited: Oct 21, 2025 at 3:41 PM
41 16mona_PHX, andrew_nyc, Dr.EndoEP and 38 others
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HealthEcon_DC
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Oct 21, 2025 at 4:49 PM#19
BethLabQueen said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Pushing back on BethLabQueen here. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

Last edited: Oct 21, 2025 at 6:49 PM
40 15TirzTom, TrialTracker_MD, JennaRN and 37 others
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mike_mod
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Oct 21, 2025 at 7:57 PM#20

Moderator note: a couple of off-topic posts removed. No action needed from anybody.

18 18PurityPaulOR, MaxMetOK, MounjBrad and 15 others
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