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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsSmall molecule vs peptide GLP-1 agonists — anyone have experience? Page 6

Small molecule vs peptide GLP-1 agonists — anyone have experience?

jason_paloalto Thu, Sep 18, 2025 at 10:31 PM 33 replies 1,842 viewsPage 6 of 7
MariaRD
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Oct 28, 2025 at 10:18 AM#26
Dr.EndoEP said:
The mechanism and the magnitude are separate questions.

Second this. I had assumed I was the exception until I read this.

45 20Dr.NutriCornell, pam_stl, wei_SG and 42 others
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Dr.CardioMD
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Nov 2, 2025 at 8:25 AM#27
Dr.EndoEP said:
The mechanism and the magnitude are separate questions.

Adding the part of the answer the thread has not reached. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

That is the short version; the long version is somebody else's post.

44 19Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 41 others
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PharmacoVig_BOS
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Nov 7, 2025 at 6:35 AM#28

The figures, for anyone assembling their own picture. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

43 18DataDave, Dr.GutHealth, amsterdam_pete and 40 others
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VanRx_Mike
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Nov 12, 2025 at 4:48 AM#29

Following on from Dr.EndoEP — and this may be the naive question:

What would you measure differently if you were starting again?

42 17Dr.Martinez, mike_mod, SarahChen_PharmD and 39 others
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jason_paloalto
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Nov 17, 2025 at 3:04 AM#30

Reporting back.

Coming back a few months on. It held. Nothing dramatic to report, which is the report.

20 20Dr.EndoEP, GraceAZ_72, carl_compliance and 17 others
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