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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsWait so orforglipron means no injection AND no fasting? Sign me up — need advice Page 2

Wait so orforglipron means no injection AND no fasting? Sign me up — need advice

JessicaM_2024 Sat, Jun 14, 2025 at 8:24 AM 8 replies 1,346 viewsPage 2 of 2
Dr.NateNeph
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Jun 14, 2025 at 9:31 AM#6
Dr.ObesityLA said:
Start from the measurement rather than the conclusion.

Pushing back on Dr.ObesityLA here. Small molecule does not automatically mean cheap. Price is set by what the market will bear and by patent life, not by cost of goods, and I would not assume the savings reach patients.

Correct me if the detail matters more than I have assumed.

14 9JakeSmashed95, NauseaFreeNow, SteveThurs and 11 others
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quinn_sf
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Jun 14, 2025 at 9:57 AM#7

Adding the numbers, since they settle part of this. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

13 8Dr.PathRoch, mona_PHX, andrew_nyc and 10 others
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LindaRN_retired
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Jun 14, 2025 at 10:23 AM#8
Dr.NateNeph said:
Small molecule does not automatically mean cheap.

There is a second half to this that has not been said yet. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

12 7amsterdam_pete, LondonLisa, mike_nyc and 9 others
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Dr.EndoIndy
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Indianapolis, IN
Jun 14, 2025 at 10:49 AM#9

A narrower follow-up, since the general answer is now clear:

How long did you give it before you decided it was working?

11 6DeniseRN_TPA, SandraNC_45, Dr.EndoIndy and 8 others
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JessicaM_2024
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Portland, OR
Jun 14, 2025 at 12:56 PM#10

OP back with an update, since a thread like this is useless without one.

Closing this out. What actually changed my mind was the point about waiting for a trend instead of reading a single measurement, which is embarrassing in hindsight and worth saying anyway.

Last edited: Jun 14, 2025 at 1:56 PM
37 10kevin_tulsa, Dr.PainCLE, mike_mealprep and 34 others
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