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ForumsOral GLP-1 AgonistsOral vs injectable GLP-1: bioavailability and efficacy comparison — need advice Page 3

Oral vs injectable GLP-1: bioavailability and efficacy comparison — need advice

mike_mealprep Wed, Mar 26, 2025 at 3:34 PM 12 replies 1,712 viewsPage 3 of 3
Dr.ReproEndo
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Mar 31, 2025 at 10:47 AM#11
Dr.RaviCardio said:
PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.

No disagreement with Dr.RaviCardio. One condition attached. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.

Last edited: Mar 31, 2025 at 11:47 AM
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lori_vegas
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Mar 31, 2025 at 6:32 PM#12
mike_mod said:
The mechanism is more central than most summaries suggest.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. I will report back once I have actually tried it.

2 0bbq_ray_KC, oliver_london
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FitDadDave
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Apr 1, 2025 at 2:16 AM#13
Dr.RaviCardio said:
PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

Last edited: Apr 1, 2025 at 5:16 AM
3 1sarah_TO, wendy_avl, jason_paloalto
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HPLC_Greg
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Apr 1, 2025 at 10:00 AM#14

The figures, for anyone assembling their own picture. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

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Admin
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Apr 1, 2025 at 5:44 PM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Carry on.

Last edited: Apr 1, 2025 at 9:44 PM
5 3PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 2 others
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