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ForumsPublic SquareSemaglutide and gallbladder disease risk — cholelithiasis incidence data Page 4

Semaglutide and gallbladder disease risk — cholelithiasis incidence data

PharmacoVig_BOS Mon, Apr 27, 2026 at 4:52 AM 23 replies 824 viewsPage 4 of 5
zoe_NC
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Nov 2024
Charlotte, NC
May 2, 2026 at 8:23 AM#16
PeptideChemSF said:
Gallbladder ultrasound monitoring on gallbladder risk: given the known gallstone risk with rapid weight loss, my doctor orders gallbladder ultrasound…

Same pattern here, and in the same order. I had assumed I was the exception until I read this.

14 12Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 11 others
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dave_SLC
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Aug 2024
Salt Lake City, UT
May 3, 2026 at 3:25 AM#17

A narrower follow-up, since the general answer is now clear:

What the dose-response curve actually looks like above 1.7mg, because the trial means hide how few people account for the extra loss?

15 13NicoleRaleigh, james_edin, FranDenver and 12 others
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MaxMetOK
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Dec 2024
Oklahoma
May 3, 2026 at 10:27 PM#18
Dr.AddMedPHL said:
Gallbladder warning for gallbladder risk: rapid weight loss increases gallstone risk regardless of method.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

16 14DoseLogDan, SleepFixSam, PurityPaulOR and 13 others
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cory_ATX
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Jul 2024
Austin, TX
May 4, 2026 at 5:28 PM#19
Dr.AddMedPHL said:
Gallbladder warning for gallbladder risk: rapid weight loss increases gallstone risk regardless of method.

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

17 15Dr.PathRoch, mona_PHX, andrew_nyc and 14 others
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mike_mod
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New York
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May 5, 2026 at 12:29 PM#20

Moderator note: the sourcing question belongs in the vendor section and has been split out. Tagging this one for the weekly digest.

39 12PurityPaulOR, MaxMetOK, MounjBrad and 36 others
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