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ForumsOral GLP-1 AgonistsOrforglipron and hepatic first-pass metabolism — anyone have experience? Page 9

Orforglipron and hepatic first-pass metabolism — anyone have experience?

Dr.EM_Chicago Fri, Jan 31, 2025 at 6:59 PM 44 replies 1,967 viewsPage 9 of 9
CanadaChris
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Mar 8, 2025 at 2:06 AM#41
PharmacoVig_BOS said:
Keep the original post as written when you update it, and add the correction underneath.

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

Last edited: Mar 8, 2025 at 8:06 AM
36 9Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 33 others
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Dr.AddMedPHL
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Mar 9, 2025 at 12:31 PM#42
PharmacoVig_BOS said:
Keep the original post as written when you update it, and add the correction underneath.

This is exactly what I could not find anywhere else. Sending this to two other people who asked me the same thing last week.

37 10sarah_nash92, FitDadDave, RunnerRach and 34 others
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mike_mod
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Mar 10, 2025 at 10:56 PM#43

Moderator note: the sourcing question belongs in the vendor section and has been split out. No action needed from anybody.

Last edited: Mar 11, 2025 at 12:56 AM
38 11DoseLogDan, SleepFixSam, PurityPaulOR and 35 others
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PurityPaulOR
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Mar 12, 2025 at 9:20 AM#44
CanadaChris said:
No disagreement, though the timescale matters more than the mechanism here.

Can confirm. Same sequence, different timescale. I had assumed I was the exception until I read this.

39 12Dr.Martinez, mike_mod, SarahChen_PharmD and 36 others
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jason_paloalto
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Mar 13, 2025 at 7:43 PM#45
CanadaChris said:
No disagreement, though the timescale matters more than the mechanism here.

Adding the part of the answer the thread has not reached. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.

Worth separating that from liver and MASH, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Last edited: Mar 14, 2025 at 12:43 AM
40 13Dr.EndoEP, GraceAZ_72, carl_compliance and 37 others
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