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ForumsPublic SquareGLP-1 therapy in patients over 65 — safety and efficacy data

GLP-1 therapy in patients over 65 — safety and efficacy data

GraceAZ_72 Sun, Apr 5, 2026 at 11:59 AM 40 replies 1,293 viewsPage 1 of 8
GraceAZ_72
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Apr 5, 2026 at 11:59 AM#1

The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

The bit I cannot resolve on my own is how people separated a drug effect from the ordinary consequences of a large deficit and disrupted sleep, because I cannot.

Numbers rather than impressions, if you have them.

40 10MariaRD, AussieAnna, BethLabQueen and 37 others
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Dr.CardioMD
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Apr 5, 2026 at 12:44 PM#2
GraceAZ_72 said:
The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

Mood changes on mental health: I want to be transparent — I went through a rough patch emotionally around month 2. Not depression exactly, but a weird flatness. Food was my main coping mechanism and without that, I had to develop new ones.

Therapy has been essential. I'd strongly recommend anyone starting GLP-1 therapy also invest in mental health support. The physical transformation is only half the journey.

39 9Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 36 others
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MeganSA_TX
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Apr 5, 2026 at 1:30 PM#3
Dr.CardioMD said:
Mood changes on mental health: I want to be transparent — I went through a rough patch emotionally around month 2.

Therapy insights from my mental health journey: my therapist introduced me to the concept of "identity updating" — the psychological work of becoming a new version of yourself.

Key realizations: I used food to manage emotions, I had internalized fatphobia that I'm still unpacking, my social identity was partly built around being "the big guy/girl," and learning to accept compliments is surprisingly hard when you've been invisible for years.

Physical transformation without emotional processing is unstable. Do both.

38 8JessicaM_2024, TomFromTexas, mike.trainer_LA and 35 others
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JenMemphis
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Memphis, TN
Apr 5, 2026 at 2:16 PM#4
GraceAZ_72 said:
The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

Same experience, arrived at from the opposite direction. Posting only so the count is not one.

Last edited: Apr 5, 2026 at 7:16 PM
37 7wanda_boise, NurseAsh_DET, BenResearch_OR and 34 others
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Dr.LeslieOBGYN
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Apr 5, 2026 at 6:32 PM#5

Adding the clinical framing, because it changes how the question reads.

Anxiety increase on mental health: counterintuitive, but losing weight rapidly triggered anxiety for me. Change — even positive change — is stressful. I was anxious about regaining weight.

This is more common than people admit. A therapist who specializes in weight management has been invaluable. Don't neglect the mental health side of this journey.

36 6mike_mealprep, NicoleRaleigh, james_edin and 33 others
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