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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPsychological & BehavioralMy relationship with food has completely changed and I am grieving it — need advice

My relationship with food has completely changed and I am grieving it — need advice

Dr.ReproEndo Mon, Nov 17, 2025 at 9:03 PM 28 replies 1,286 viewsPage 1 of 6
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Dr.ReproEndo
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Nov 17, 2025 at 9:03 PM#1

My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer have my main coping mechanism.

What I actually want to know is how people separated a drug effect from the ordinary consequences of a large deficit and disrupted sleep, because I cannot.

Tell me what I have not thought of.

43 13mona_PHX, andrew_nyc, Dr.EndoEP and 40 others
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KevinCompounds
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Nov 17, 2025 at 11:29 PM#2
Dr.ReproEndo said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…

Anxiety increase on mental health: counterintuitive, but losing weight rapidly triggered anxiety for me. Change — even positive change — is stressful. I was anxious about people treating me differently.

This is more common than people admit. A therapist who specializes in weight management has been invaluable. Don't neglect the mental health side of this journey.

Last edited: Nov 18, 2025 at 1:29 AM
42 12Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 39 others
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gary_naperville
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Nov 18, 2025 at 1:55 AM#3
KevinCompounds said:
Anxiety increase on mental health: counterintuitive, but losing weight rapidly triggered anxiety for me.

Recovering from an eating disorder and using mental health: this is a complex situation and I want to be transparent about it.

I have a history of binge eating disorder. My psychiatrist, therapist, and prescribing doctor all collaborate on my care. The GLP-1 agonist has actually been therapeutic — it removes the biological urgency of binge impulses without relying on restriction.

This is NOT appropriate for all ED patients. Anorexia, bulimia, and restrictive EDs require different approaches. But for BED specifically, the evidence and my personal experience are positive. Always involve your mental health team.

41 11TomTeleRx, DoseLogDan, SleepFixSam and 38 others
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MikeKY_noInsulin
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Oct 2024
Louisville, KY
Nov 18, 2025 at 4:21 AM#4
Dr.ReproEndo said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…

Mine went the same way, slower.

40 10amy_econ_NJ, bbq_ray_KC, oliver_london and 37 others
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Dr.ObesityLA
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Nov 18, 2025 at 6:58 PM#5

Adding the clinical framing, because it changes how the question reads.

Dr.ReproEndo said:
...mental health should only be used alongside therapy...

I'd say therapy should be AVAILABLE to all GLP-1 patients, but requiring it as a precondition for treatment would create an access barrier.

Not everyone can afford therapy. Not everyone needs it. Some people do just fine with medication + lifestyle changes. But for those with emotional eating, body image issues, or disordered eating history, therapy is extremely valuable.

My recommendation: make mental health screening part of the initial assessment, offer therapy as a recommended adjunct, but don't gatekeep medication access behind it.

39 9jason_sac26, chris_chi24, tampaLisa73 and 36 others
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