Dr.EndoEP said:Dose-response modeling for tirzepatide: Emax model fitting to the STEP/SURMOUNT dose-finding data shows: Semaglutide: ED50 ≈ 0.6mg, Emax ≈ -18%, Hill…
Second this. I had assumed I was the exception until I read this.
jason_paloalto said:The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…
Can confirm. Same sequence, different timescale.
jason_paloalto said:The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…
There is a second half to this that has not been said yet. The pharmacokinetics explain nearly every practical question asked here. Albumin binding above 99% slows clearance enough to make weekly dosing possible; a terminal half-life near a week means four to five weeks to steady state and therefore a four-week titration interval; subcutaneous bioavailability around 89% means injection site barely matters. Those three facts answer most timing questions before they are asked.
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Browse GL BiochemOne concrete data point for the thread. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.