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ForumsTirzepatide (Mounjaro / Zepbound)SURMOUNT-OSA: tirzepatide and sleep apnea AHI reduction Page 3

SURMOUNT-OSA: tirzepatide and sleep apnea AHI reduction

SleepDoc_PDX Fri, Jun 5, 2026 at 7:06 AM 12 replies 308 viewsPage 3 of 3
raj_cambridge
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Jun 8, 2026 at 4:35 AM#11
traveltech_sara said:
SURMOUNT-1 landed around 20.9% mean weight loss at 15mg over 72 weeks, against roughly 15% for semaglutide 2.4mg in STEP 1.

This is exactly what I could not find anywhere else. I will report back once I have actually tried it.

Last edited: Jun 8, 2026 at 5:35 AM
25 0SleepFixSam, PurityPaulOR, MaxMetOK and 22 others
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Dr.KarenChen
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Jun 8, 2026 at 7:40 AM#12

Adding the clinical framing, because it changes how the question reads.

Month 8 update on sleep apnoea: down 20 lbs from my starting weight of 255 lbs. Here's what's changed beyond the scale:

  • No longer pre-diabetic (A1C normalized)
  • Off blood pressure medication
  • Can tie my shoes without getting winded
  • Sleep apnea resolved — returned my CPAP
  • Confidence level: through the roof

This medication has genuinely given me my life back. I'm not exaggerating. 🙌

24 24JessicaM_2024, TomFromTexas, mike.trainer_LA and 21 others
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LabKate
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Jun 8, 2026 at 10:44 AM#13
Dr.SleepRoch said:
The GIP arm is doing real work rather than padding the label.

Sleep changes on sleep apnoea: anyone else sleeping differently? I've been sleeping worse since starting week 3.

My theory: the weight loss has improved my sleep apnea (confirmed by recent sleep study — AHI dropped from 28 to 4). Better oxygenation at night = better sleep quality = more energy during the day. It's a virtuous cycle.

Last edited: Jun 8, 2026 at 1:44 PM
23 23Dr.SleepRoch, laura_annarbor, JenMemphis and 20 others
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Dr.GutHealth
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Jun 8, 2026 at 1:49 PM#14

One concrete data point for the thread. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

22 22Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 19 others
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Admin
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Jun 8, 2026 at 4:53 PM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Thread quality here is what the rules are for. Keep it up.

21 21PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 18 others
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