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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsRybelsus on an empty stomach is ruining my mornings — anyone have experience? Page 3

Rybelsus on an empty stomach is ruining my mornings — anyone have experience?

PharmacoVig_BOS Mon, Jul 22, 2024 at 1:04 PM 41 replies 2,693 viewsPage 3 of 9
Dr.SportsMedIN
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Jul 24, 2024 at 10:25 PM#11
Dr.PeteFamMed said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

Last edited: Jul 25, 2024 at 3:25 AM
26 1lucas_SP_BR, lisa_labSD, adam_van and 23 others
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ingrid_STO
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Jul 26, 2024 at 5:15 AM#12
ZaraB_AL said:
The absorption variability is real, but it partly averages out over weeks — the steady-state trough is less erratic than any single day would suggest.

Bookmarking. The distinction being drawn above is the one nobody else makes. I will report back once I have actually tried it.

25 0COA_Karl, MikeFit_NJ, InsuranceTom and 22 others
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hank_denver
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Jul 27, 2024 at 12:06 PM#13
Dr.PeteFamMed said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

24 24denise_HTX, raj_cambridge, ingrid_STO and 21 others
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TirzTom
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Jul 28, 2024 at 6:58 PM#14

Adding the numbers, since they settle part of this. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

23 23SandraNC_45, Dr.EndoIndy, tom_AK and 20 others
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mike_mod
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Jul 30, 2024 at 1:50 AM#15

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Report rather than reply if it drifts again.

22 22PurityPaulOR, MaxMetOK, MounjBrad and 19 others
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