Clinical perspective, offered as context rather than as advice. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.
anders_CPH said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.
anders_CPH said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
Agreeing with anders_CPH, and the qualification matters more than the agreement. Worth adding the genuine exception, because it is real and narrow: a change made for an identified patient where the prescriber determines it produces a significant clinical difference for that patient. A grid of fixed doses offered to everybody is not that, whatever the intake form says.
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Browse GL Biochemanders_CPH said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
This answered a question I did not know how to ask. I will report back once I have actually tried it.
Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Report rather than reply if it drifts again.