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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPublic SquareDoes anyone else feel like they are in a secret club now Page 3

Does anyone else feel like they are in a secret club now

SaraMom3 Thu, Jan 15, 2026 at 5:24 PM 42 replies 1,262 viewsPage 3 of 9
FDA_TrackerJim
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Jan 17, 2026 at 6:43 AM#11
TinaHashiRN said:
Dr.AddMedPHL said: ...regarding the trial evidence...

True, and it depends on a baseline nobody has stated. Without knowing where someone started, the same number can be an excellent result or a disappointing one.

Last edited: Jan 17, 2026 at 9:43 AM
23 23Dr.Martinez, mike_mod, SarahChen_PharmD and 20 others
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KetoKyle
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Jan 18, 2026 at 8:06 AM#12
SandraNC_45 said:
Forest plot interpretation for the the trial evidence meta-analysis: when reading the pooled estimate, pay attention to: Point estimate (HR/RR/OR) —…

Thank you for spelling out the reasoning rather than just the conclusion. Printing the relevant bit and taking it with me.

22 22JenMemphis, pat_auckland, Dr.GastroMayo and 19 others
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BiostatsBrad
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Jan 19, 2026 at 9:30 AM#13
TinaHashiRN said:
Dr.AddMedPHL said: ...regarding the trial evidence...

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

I would rather be corrected than agreed with, if it comes to it.

21 21FranDenver, Dr.BariatricHTX, LindaRN_retired and 18 others
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wendy_avl
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Jan 20, 2026 at 10:54 AM#14

Adding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

20 20PharmHunterJen, TomTeleRx, DoseLogDan and 17 others
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mike_mod
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Jan 21, 2026 at 12:19 PM#15

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Report rather than reply if it drifts again.

19 19PurityPaulOR, MaxMetOK, MounjBrad and 16 others
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