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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPublic SquareStarted this morning and already overthinking everything Page 3

Started this morning and already overthinking everything

hannah_MT Sat, Jan 3, 2026 at 12:20 PM 13 replies 1,158 viewsPage 3 of 3
Dr.BariatricHTX
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Jan 6, 2026 at 8:39 AM#11
DeniseRN_TPA said:
Bayesian meta-analysis perspective on the trial evidence: traditional frequentist meta-analyses report point estimates and confidence intervals.

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

Last edited: Jan 6, 2026 at 2:39 PM
44 19CarlaRPh_TPA, steph_laguna, fiona_glasgow and 41 others
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mel_PDX
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Jan 8, 2026 at 2:45 AM#12
josh_phd_bmore said:
Forest plot interpretation for the the trial evidence meta-analysis: when reading the pooled estimate, pay attention to: Point estimate (HR/RR/OR) —…

That reframing is the part I needed. Sending this to two other people who asked me the same thing last week.

43 18Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 40 others
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Dr.MetabolicMD
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Jan 9, 2026 at 8:51 PM#13
DeniseRN_TPA said:
Bayesian meta-analysis perspective on the trial evidence: traditional frequentist meta-analyses report point estimates and confidence intervals.

I read this differently from DeniseRN_TPA, on substance rather than tone. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

42 17HealthEcon_DC, PedsEndoPhilly, SleepDoc_PDX and 39 others
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DataDave
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Jan 11, 2026 at 2:58 PM#14

The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

41 16amsterdam_pete, LondonLisa, mike_nyc and 38 others
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Admin
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Jan 13, 2026 at 9:06 AM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Report rather than reply if it drifts again.

Last edited: Jan 13, 2026 at 1:06 PM
40 15PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 37 others
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