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ForumsPsychological & BehavioralCognitive effects of GLP-1 agonists — July 2024 Page 2

Cognitive effects of GLP-1 agonists — July 2024

SandraNC_45 Tue, Sep 2, 2025 at 3:30 PM 12 replies 1,380 viewsPage 2 of 3
BethLabQueen
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Sep 2, 2025 at 6:14 PM#6
SandraNC_45 said:
The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously.

Body image adjustment with mental health: I've lost 58 lbs but when I look in the mirror, I still see my old self sometimes. "Phantom fat" is a real phenomenon.

My therapist specializes in body image issues with weight loss patients. She says it can take 12-18 months for your brain's body map to update. In the meantime: take progress photos (your eyes lie but cameras don't), try on old clothes, and be patient with yourself.

43 13maya_sedona, stefan_berlin, Dr.EM_Chicago and 40 others
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DerekSJ_a1c
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Sep 2, 2025 at 7:18 PM#7

Following on from BariatricNurseD — and this may be the naive question:

Did your prescriber agree with that reading, and if not what was their objection?

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julia.endo
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Sep 2, 2025 at 8:22 PM#8
BethLabQueen said:
Body image adjustment with mental health: I've lost 58 lbs but when I look in the mirror, I still see my old self sometimes.

When to call your doctor about mental health side effects — a reference I wish I'd had:

Call immediately:

  • Severe abdominal pain (could be pancreatitis)
  • Vision changes (thyroid concern)
  • Lump in neck (thyroid nodule)
  • Severe vomiting/can't keep fluids down for 24h+

Schedule an appointment:

  • Persistent nausea beyond 4 weeks
  • Significant hair loss
  • Mood changes or depression
  • Gallbladder symptoms (RUQ pain after eating)
Last edited: Sep 3, 2025 at 2:22 AM
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SandraNC_45
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Sep 2, 2025 at 9:26 PM#9

Closing the loop on my own question.

Follow-up — I put something in the gap where food used to be rather than waiting for the gap to close on its own. That was the part nobody told me.

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rachel_ABQ
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Sep 3, 2025 at 2:34 AM#10
julia.endo said:
When to call your doctor about mental health side effects — a reference I wish I'd had: Call immediately: Severe abdominal pain (could be…

Mood changes on mental health: I want to be transparent — I went through a rough patch emotionally around month 3. Not depression exactly, but a weird flatness. Food was my main coping mechanism and without that, I had to develop new ones.

Therapy has been essential. I'd strongly recommend anyone starting GLP-1 therapy also invest in mental health support. The physical transformation is only half the journey.

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