From the other side of the consultation, briefly. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
Adding the numbers, since they settle part of this. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.
A narrower follow-up, since the general answer is now clear:
What would you measure differently if you were starting again?
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View Resultskate.chem said:Practical: whatever you change, write down the date and the reason.
I read this differently from kate.chem, on substance rather than tone. Steady state is the thing most people miss. The terminal half-life is about a week, so every dose step takes four to five weeks to fully express itself. Judging a step at day ten is judging the ascent, not the plateau, and it is the single commonest reason people escalate before they needed to.
Moderator note: the sourcing question belongs in the vendor section and has been split out. No action needed from anybody.