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ForumsPublic SquareSemaglutide and addictive behavior reduction — need advice Page 5

Semaglutide and addictive behavior reduction — need advice

Dr.RenalNash Fri, Sep 19, 2025 at 1:34 AM 30 replies 1,683 viewsPage 5 of 6
DadBodDave
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Nov 2024
Ohio
Sep 21, 2025 at 5:45 PM#21
InsuranceTom said:
Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak.

Same experience, arrived at from the opposite direction. Posting only so the count is not one.

29 4laura_annarbor, JenMemphis, pat_auckland and 26 others
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EndoResFellow
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Baltimore, MD
Sep 22, 2025 at 3:46 AM#22
InsuranceTom said:
Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak.

There is a second half to this that has not been said yet. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

28 3TinaHashiRN, robert_kc, dan_philly and 25 others
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stefan_berlin
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Oct 2024
Berlin, DE
Sep 22, 2025 at 1:47 PM#23

The figures, for anyone assembling their own picture. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Happy to go further on any of that.

Last edited: Sep 22, 2025 at 4:47 PM
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JakeBK_lifts
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Jul 2024
Brooklyn, NY
Sep 22, 2025 at 11:48 PM#24

One thing that is still open after InsuranceTom’s answer:

How would you tell the difference between that and the alternative explanation?

Last edited: Sep 23, 2025 at 1:48 AM
26 1kate.chem, DataDave, Dr.GutHealth and 23 others
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TomFromTexas
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Austin, TX
Sep 23, 2025 at 9:50 AM#25
stefan_berlin said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

25 0BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 22 others
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