newstart_MO said:

Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five.

Sleep changes on sleep apnoea: anyone else sleeping differently? I've been sleeping more deeply since starting week 4.

My theory: the weight loss has improved my sleep apnea (confirmed by recent sleep study — AHI dropped from 25 to 6). Better oxygenation at night = better sleep quality = more energy during the day. It's a virtuous cycle.

carlos_SATX said:

Agreed on the mechanism, with the caveat that the head-to-head used semaglutide 1mg, not 2.4mg.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Printing the relevant bit and taking it with me.

newstart_MO said:

Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. The counter-case has not been addressed. Somebody upthread described the situation that does not fit, and the thread moved on rather than engaging with it, which is the failure mode this board is supposed to avoid.

The figures, for anyone assembling their own picture. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Moderator note: a couple of off-topic posts removed. Tagging this one for the weekly digest.