Dr.RenalNash said:

The useful move here is to separate what is established from what is widely repeated.

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

julia.endo said:

My experience ordering cross-border ordering internationally: I've ordered from an Australian compounder.

Genuinely useful, thank you. I had the facts and not the framework.

Dr.RenalNash said:

The useful move here is to separate what is established from what is widely repeated.

Pushing back on Dr.RenalNash here. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

The figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful.