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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)Tirzepatide 15mg — looking for input Page 5

Tirzepatide 15mg — looking for input

NurseAsh_DET Sun, Jan 4, 2026 at 10:18 AM 34 replies 1,751 viewsPage 5 of 7
Dr.PeteFamMed
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Jan 7, 2026 at 12:18 PM#21
NurseLeah_Nash said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Adding the part of the answer the thread has not reached. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

16 16hyun_seoul, jim_asheville, matt_MKE and 13 others
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FDA_TrackerJim
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Jan 8, 2026 at 2:04 AM#22

Adding the numbers, since they settle part of this. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

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paige_pharma
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Jan 8, 2026 at 3:50 PM#23

One thing that is still open after NurseLeah_Nash’s answer:

What did you change at the same time, and can you separate the two now?

14 14adam_van, Dr.SurgeonPGH, rachel_ABQ and 11 others
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DadBodDave
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Jan 9, 2026 at 5:36 AM#24
FDA_TrackerJim said:
Worth stating the units and the reference range whenever you post a number here.

Pushing back on FDA_TrackerJim here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

13 13Dr.GastroMayo, JakeBK_lifts, DerekSJ_a1c and 10 others
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JennaRN
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Jan 9, 2026 at 7:23 PM#25
FDA_TrackerJim said:
Worth stating the units and the reference range whenever you post a number here.

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

Correct me if the detail matters more than I have assumed.

12 12SleepDoc_PDX, RegAffairsDC, BiostatsBrad and 9 others
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