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ForumsPublic SquareGLP-1 and dental health — March 2026 Page 3

GLP-1 and dental health — March 2026

mike_nyc Thu, Jan 9, 2025 at 12:06 PM 12 replies 1,780 viewsPage 3 of 3
nick_newbie
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Jan 14, 2025 at 12:16 AM#11
sarah_TO said:
Relative and absolute effects need reading together.

Thank you for spelling out the reasoning rather than just the conclusion. I will report back once I have actually tried it.

Last edited: Jan 14, 2025 at 3:16 AM
38 13robert_kc, dan_philly, MeganSA_TX and 35 others
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SarahChen_PharmD
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Jan 16, 2025 at 4:01 AM#12

Adding the clinical framing, because it changes how the question reads.

Propensity score matching studies and the trial evidence: when RCTs aren't available for a specific question, propensity score-matched observational studies can provide useful evidence.

A recent PSM study of 12,000 GLP-1 users vs matched controls showed reduced heart failure hospitalization (HR 0.74) over 3 years of follow-up[1].

These results complement the RCT data and suggest the benefits translate to real-world populations.

References:
[1] Registry-based cohort study, pre-print 2024.
37 12NurseKim_ATL, paul_denver, TinaHashiRN and 34 others
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julia.endo
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Jan 18, 2025 at 7:47 AM#13
PedsEndoPhilly said:
Forest plot interpretation for the the trial evidence meta-analysis: when reading the pooled estimate, pay attention to: Point estimate (HR/RR/OR) —…

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

Last edited: Jan 18, 2025 at 1:47 PM
36 11hans_munich, jason_sac26, chris_chi24 and 33 others
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DataDave
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Jan 20, 2025 at 11:34 AM#14

Adding the numbers, since they settle part of this. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

Last edited: Jan 20, 2025 at 12:34 PM
35 10amsterdam_pete, LondonLisa, mike_nyc and 32 others
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mike_mod
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Jan 22, 2025 at 3:22 PM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Carry on.

34 9PurityPaulOR, MaxMetOK, MounjBrad and 31 others
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