TrialNerd_Beth said:

Compounded has been just as effective for me.

I have been on both brand and compounded, and in the context of compounded supply, my experience has been equivalent with both. The key is finding a reliable 503B pharmacy with independent testing.

GraceAZ_72 said:

Agreed, and the enforcement dates were staggered by category — 503A first, 503B a few weeks later — because outsourcing facilities have manufactured…

This answered a question I did not know how to ask. Sending this to two other people who asked me the same thing last week.

TrialNerd_Beth said:

Compounded has been just as effective for me.

Price comparison for compounded supply across sources I've used:

I use the 503B option — best balance of quality, cost, and legality. The brand price is insane but insurance can help if you qualify.

WendyG_ATL said:

My pharmacy stopped supplying with three weeks notice and a letter that explained nothing, so I went and read the statute.

For compounded supply users considering compounded for the first time: here's a step-by-step guide:

1. Get a prescription from your doctor (telehealth counts)
2. Research 503B compounding pharmacies with good community reviews
3. Verify their FDA registration and inspection history
4. Request a COA for your specific compound before ordering
5. Start with a 1-month supply to test
6. Consider sending a sample to Janoshik for independent verification
7. Track your response compared to brand (if you were on it previously)

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Carry on.