Dr.SurgeonPGH said:The gap between trial results and real-world results is consistent and it is not fraud.
Agreed, and subgroup analyses deserve particular suspicion. With enough subgroups something is significant by chance, and pre-registered subgroups are a different animal from ones found afterwards.
Ask again with the specifics and you will get a better answer than this one.
tony_orlando said:Agreed on the mechanism, with the caveat that the head-to-head used semaglutide 1mg, not 2.4mg.
This answered a question I did not know how to ask. Adding it to my notes with a link back to this thread.
Dr.SurgeonPGH said:The gap between trial results and real-world results is consistent and it is not fraud.
I read this differently from Dr.SurgeonPGH, on substance rather than tone. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.
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View ResultsOne concrete data point for the thread. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.
Happy to go further on any of that.
Moderator note: the sourcing question belongs in the vendor section and has been split out. Report rather than reply if it drifts again.