Found this through search years later and it is still the best discussion of the question, so adding one thing. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.
Dr.ReproEndo said:It helps to say which part of this you are uncertain about.
Coming at Dr.ReproEndo’s question from a different direction. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
The figures, for anyone assembling their own picture. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.
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View ResultsA narrower follow-up, since the general answer is now clear:
Did your prescriber agree with that reading, and if not what was their objection?
anders_CPH said:Say what you would expect to see if you were wrong, before you look.
Pushing back on anders_CPH here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.