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ForumsPublic SquareComparative pharmacokinetics: semaglutide vs tirzepatide vs retatrutide — need advice Page 8

Comparative pharmacokinetics: semaglutide vs tirzepatide vs retatrutide — need advice

emily_PDX Mon, Jul 22, 2024 at 4:07 PM 36 replies 2,470 viewsPage 8 of 8
BiostatsBrad
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Durham, NC
Aug 2, 2024 at 12:07 PM#36

One thing that is still open after sarah_TO’s answer:

How would you tell the difference between that and the alternative explanation?

Last edited: Aug 2, 2024 at 1:07 PM
21 21LindaRN_retired, tommy_boulder, hyun_seoul and 18 others
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TomTeleRx
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Feb 2025
Delaware
Aug 3, 2024 at 1:42 AM#37
labquiet_amy said:
If you are going to change something, change one thing and give it long enough to express itself.

This is where I part company with the consensus forming above. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

20 20bri_stats, pete_manc_UK, anna.melb_AU and 17 others
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sean_dublin
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Nov 2024
Dublin, IE
Aug 3, 2024 at 3:16 PM#38
labquiet_amy said:
If you are going to change something, change one thing and give it long enough to express itself.

Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

19 19gary_naperville, sean_dublin, hannah_MT and 16 others
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quinn_sf
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Jun 2024
San Francisco, CA
Aug 4, 2024 at 4:50 AM#39
labquiet_amy said:
If you are going to change something, change one thing and give it long enough to express itself.

Saving this. It is the first explanation that did not require me to already understand it.

Last edited: Aug 4, 2024 at 10:50 AM
18 18andrew_nyc, Dr.EndoEP, GraceAZ_72 and 15 others
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julia.endo
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Cincinnati, OH
Aug 4, 2024 at 6:24 PM#40

Clinical perspective, offered as context rather than as advice. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

46 21chris_chi24, tampaLisa73, KarenAZ_mom and 43 others
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