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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)5mg doing nothing - should I ask to go up? — need advice Page 3

5mg doing nothing - should I ask to go up? — need advice

Dr.LeslieOBGYN Tue, Sep 2, 2025 at 12:56 PM 12 replies 1,308 viewsPage 3 of 3
EndoResFellow
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Sep 4, 2025 at 11:12 AM#11
Dr.NutriCornell said:
SURMOUNT-1 landed around 20.9% mean weight loss at 15mg over 72 weeks, against roughly 15% for semaglutide 2.4mg in STEP 1.

Bookmarking. The distinction being drawn above is the one nobody else makes. Sending this to two other people who asked me the same thing last week.

25 0robert_kc, dan_philly, MeganSA_TX and 22 others
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Dr.LipidDallas
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Sep 4, 2025 at 10:11 PM#12

From the other side of the consultation, briefly. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

24 24wei_SG, cory_ATX, lori_vegas and 21 others
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sarah.morrison
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Sep 5, 2025 at 9:10 AM#13
SleepDoc_PDX said:
The distinction that resolves most of these threads is between what is true on average and what is true for one person.

Pushing back on SleepDoc_PDX here. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.

23 23tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 20 others
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LabKate
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Sep 5, 2025 at 8:09 PM#14

The figures, for anyone assembling their own picture. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

22 22emily_PDX, Dr.SleepRoch, laura_annarbor and 19 others
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Admin
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Sep 6, 2025 at 7:09 AM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. No action needed from anybody.

21 21PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 18 others
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