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Evidence-based GLP-1 & peptide discussion since 2023
ForumsClinical Trials & ResearchCan we talk about how SLOW the FDA is Page 3

Can we talk about how SLOW the FDA is

KarenAZ_mom Mon, Apr 20, 2026 at 10:27 AM 38 replies 1,036 viewsPage 3 of 8
JennaRN
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Apr 21, 2026 at 12:47 PM#11
chris_chi24 said:
Forest plot interpretation for the the trial evidence meta-analysis: when reading the pooled estimate, pay attention to: Point estimate (HR/RR/OR) —…

No disagreement, though it depends on where somebody is starting from, and this thread has been assuming a starting point nobody stated.

I would rather be corrected than agreed with, if it comes to it.

Last edited: Apr 21, 2026 at 1:47 PM
36 11Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 33 others
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raj_cambridge
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Apr 22, 2026 at 12:46 AM#12
tampaLisa73 said:
Bayesian meta-analysis perspective on the trial evidence: traditional frequentist meta-analyses report point estimates and confidence intervals.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Adding it to my notes with a link back to this thread.

Last edited: Apr 22, 2026 at 1:46 AM
35 10DoseLogDan, SleepFixSam, PurityPaulOR and 32 others
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DadBodDave
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Apr 22, 2026 at 12:45 PM#13
chris_chi24 said:
Forest plot interpretation for the the trial evidence meta-analysis: when reading the pooled estimate, pay attention to: Point estimate (HR/RR/OR) —…

Pushing back on chris_chi24 here. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

I would rather be corrected than agreed with, if it comes to it.

Last edited: Apr 22, 2026 at 3:45 PM
34 9pat_auckland, Dr.GastroMayo, JakeBK_lifts and 31 others
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HPLC_Greg
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Apr 23, 2026 at 12:44 AM#14

Adding the numbers, since they settle part of this. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

Last edited: Apr 23, 2026 at 6:44 AM
33 8Dr.MetabolicMD, RetaRick_CA, JenPlateau and 30 others
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mike_mod
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Apr 23, 2026 at 12:43 PM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.

32 7PurityPaulOR, MaxMetOK, MounjBrad and 29 others
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