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ForumsCompounding & FormulationCompounded peptide reconstitution water — looking for input Page 3

Compounded peptide reconstitution water — looking for input

maria_elpaso Fri, Oct 18, 2024 at 11:14 PM 33 replies 2,392 viewsPage 3 of 7
bbq_ray_KC
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Oct 19, 2024 at 6:04 PM#11
Dr.PulmRoch said:
Do it in two steps and it stops being confusing.

This answered a question I did not know how to ask. I will report back once I have actually tried it.

13 13COA_Karl, MikeFit_NJ, InsuranceTom and 10 others
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VendorMark
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Oct 20, 2024 at 5:59 AM#12

Clinical perspective, offered as context rather than as advice.

Quick syringe math for dosing arithmetic dosing: if your vial is reconstituted at 5mg/2mL, that's 2.5mg/mL. For a 0.25mg dose you need 0.1mL = 10 units on an insulin syringe.

I keep a chart on my fridge:

  • 0.25mg = 10 units
  • 0.5mg = 20 units
  • 1.0mg = 40 units
  • 1.25mg = 50 units

Always double-check your concentration before drawing up!

12 12KristenIndy, MarkLI_maint, Dr.PeteFamMed and 9 others
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Dr.KarenChen
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Oct 20, 2024 at 5:54 PM#13
Dr.NateNeph said:
The shortage clause is the answer to the second question and it is a subtraction rather than an addition.

I read this differently from Dr.NateNeph, on substance rather than tone. A research-chemical supplier selling lyophilised powder labelled research use only is not compounding and is not claiming to. It is a different legal universe with no pharmacy oversight, no patient relationship and no content guarantee, and conflating the two in these threads helps nobody.

11 11TomFromTexas, mike.trainer_LA, sarah_nash92 and 8 others
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LabKate
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Oct 21, 2024 at 5:49 AM#14
maria_elpaso said:
Concentration choice is a precision decision, not a preference.

For anyone reconstituting dosing arithmetic peptides: the water-to-powder ratio determines your concentration. Here's my reference:

Vial SizeBAC WaterConcentration0.25mg Dose
5mg2mL2.5mg/mL10 units
5mg2.5mL2mg/mL12.5 units
10mg2mL5mg/mL5 units
10mg3mL3.33mg/mL7.5 units

More water = easier to measure small doses but vial runs out faster. Find the balance that works for your dose.

Last edited: Oct 21, 2024 at 8:49 AM
10 10emily_PDX, Dr.SleepRoch, laura_annarbor and 7 others
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mike_mod
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Oct 21, 2024 at 5:44 PM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Tagging this one for the weekly digest.

9 9PurityPaulOR, MaxMetOK, MounjBrad and 6 others
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