Dr.DermMIA said:

Dose-response modeling for tirzepatide: Emax model fitting to the STEP/SURMOUNT dose-finding data shows: Semaglutide: ED50 ≈ 0.6mg, Emax ≈ -18%, Hill…

Same position here, arrived at the long way round. Worth adding the genuine exception, because it is real and narrow: a change made for an identified patient where the prescriber determines it produces a significant clinical difference for that patient. A grid of fixed doses offered to everybody is not that, whatever the intake form says.

Happy to go further on any of that.

TrialTracker_MD said:

One practical note: write down what you did and when, before you need it.

That is right for the common case. Whether it is right for the case being asked about depends on a detail that has not been given.

TrialTracker_MD said:

One practical note: write down what you did and when, before you need it.

This is exactly what I could not find anywhere else. I will report back once I have actually tried it.

From the other side of the consultation, briefly. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

Moderator note: the sourcing question belongs in the vendor section and has been split out.