Dr.ObesityLA said:The GIP arm is doing real work rather than padding the label.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
WendyG_ATL said:Steady state is the thing most people miss.
Thank you — that is the clearest version of this I have read, and I have read a lot of them.
Dr.ObesityLA said:The GIP arm is doing real work rather than padding the label.
I will push back on the "any working dose is fine" framing. The maintenance evidence sits overwhelmingly at the top studied dose, and the extension data shows regain tracking dose reduction rather than tracking stopping. Holding low is reasonable; pretending it is evidentially equivalent is not.
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Browse GL BiochemThe figures, for anyone assembling their own picture. Practical numbers: half-life about 5 days, steady state 3 to 4 weeks, ladder 2.5 / 5 / 7.5 / 10 / 12.5 / 15mg, and the maintenance doses with published data behind them are 5, 10 and 15mg.
Worth separating that from tirzepatide, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
Ask again with the specifics and you will get a better answer than this one.
Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. No action needed from anybody.