TrialNerd_Beth said:

Concentration choice is a precision decision, not a preference.

I am going to disagree with reconstituting low as a general rule. More diluent, more punctures, more in-use days at room temperature, and the stability trade-off is real. Precision is not the only variable being optimised.

That is the short version; the long version is somebody else's post.

One concrete data point for the thread. Practical numbers: half-life about 5 days, steady state 3 to 4 weeks, ladder 2.5 / 5 / 7.5 / 10 / 12.5 / 15mg, and the maintenance doses with published data behind them are 5, 10 and 15mg.

BenResearch_OR said:

I am going to disagree with reconstituting low as a general rule.

Adding the part of the answer the thread has not reached. Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five. That matters when you are deciding whether a dose step has finished expressing itself.

Following on from josh_phd_bmore — and this may be the naive question:

How to check the arithmetic without trusting a website calculator, since three calculators gave me three answers?

Closing the loop on my own question.

Resolved. I wrote mg, ml and mg/ml on the vial in marker and did the division in that order, and the two of us now get the same number every time.