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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCompounding & FormulationIs it normal for the powder to not fully dissolve — July 2024 Page 5

Is it normal for the powder to not fully dissolve — July 2024

PedsEndoPhilly Wed, Feb 7, 2024 at 3:59 PM 60 replies 3,510 viewsPage 5 of 12
Dr.CardioMD
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Dec 2023
Cleveland, OH
Feb 14, 2024 at 11:08 PM#21
Dr.PainCLE said:
Compounding pharmacy response time test for compounded supply: I email customer service at odd hours to test responsiveness.

Compounded has been just as effective for me. If compounded supply is the concern, the COA from my 503B pharmacy shows 99.1% purity. Verified by Janoshik.

30 3kim_atl_prep, sarah_TO, wendy_avl and 27 others
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lisa_labSD
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Oct 2024
San Diego, CA
Feb 16, 2024 at 10:55 AM#22
Dr.PainCLE said:
Compounding pharmacy response time test for compounded supply: I email customer service at odd hours to test responsiveness.

503A vs 503B compounding pharmacies for compounded supply — this distinction matters enormously:

Feature503A503B
RegulationState Board of PharmacyFDA-registered
PrescriptionRequired (patient-specific)Can compound without patient Rx
TestingVaries by statecGMP required
ScaleSmall batchesLarger production
Quality consistencyVariableGenerally higher

I strongly recommend 503B facilities. The FDA oversight and cGMP requirements mean more consistent product quality.

Last edited: Feb 16, 2024 at 1:55 PM
31 4maya_sedona, stefan_berlin, Dr.EM_Chicago and 28 others
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Dr.EndoIndy
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Oct 2024
Indianapolis, IN
Feb 17, 2024 at 10:43 PM#23

A narrower follow-up, since the general answer is now clear:

What would you measure differently if you were starting again?

32 5marcus_mpls, DeniseRN_TPA, SandraNC_45 and 29 others
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SallyK_inj
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567
2,345
Jul 2024
Iowa
Feb 19, 2024 at 10:32 AM#24
lisa_labSD said:
503A vs 503B compounding pharmacies for compounded supply — this distinction matters enormously: Feature 503A 503B Regulation State Board of Pharmacy…

Regarding compounded supply compounding legality: compounding pharmacies can legally produce semaglutide and tirzepatide while these drugs remain on the FDA shortage list. If/when the shortage resolves, the legal landscape may change.

Stay informed. The FDA shortage list is updated regularly. Current status as of my last check: semaglutide partially resolved shortage, tirzepatide still in shortage. This directly impacts compounding availability.

33 6tane_welly, Dr.PathRoch, mona_PHX and 30 others
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quinn_sf
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Jun 2024
San Francisco, CA
Feb 20, 2024 at 10:21 PM#25
lisa_labSD said:
503A vs 503B compounding pharmacies for compounded supply — this distinction matters enormously: Feature 503A 503B Regulation State Board of Pharmacy…

Compounding pharmacy red flag checklist for compounded supply — if ANY of these apply, find a different source:

  1. No verifiable physical address
  2. No pharmacist available for consultation
  3. COA not available or clearly template/fake
  4. Prices dramatically below market ($30-40/month = suspicious)
  5. No prescription required
  6. Ships without cold pack or temperature control
  7. No batch/lot numbers on product labeling
  8. Pushes "research use only" products for human injection

Your health depends on product quality. Don't cut corners on source verification.

Last edited: Feb 21, 2024 at 4:21 AM
34 7Dr.EndoEP, GraceAZ_72, carl_compliance and 31 others
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