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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)Tirzepatide and cholesterol — looking for input Page 5

Tirzepatide and cholesterol — looking for input

wei_SG Mon, Jan 20, 2025 at 4:31 PM 44 replies 2,688 viewsPage 5 of 9
Dr.ObesityMed
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Jan 23, 2025 at 11:04 AM#21
wendy_avl said:
Before/after bloodwork compilation for the lipid panel — everything in one place for those who want comprehensive data: Category Marker Before After…

Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel:

MarkerBaselineMonth 8Clinical Meaning
LDL-P1538938Particle count (more precise than LDL-C)
Small dense LDL68%30%Atherogenic pattern
Remnant cholesterol4217Triglyceride-rich lipoproteins
oxLDL8346Oxidative stress marker

The shift from small dense to large buoyant LDL is particularly important — it represents a fundamental change in the atherogenic profile.

37 10EndoResFellow, PharmacoVig_BOS, SurmountFan_IN and 34 others
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pam_columbus
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Jan 24, 2025 at 1:59 AM#22
wendy_avl said:
Before/after bloodwork compilation for the lipid panel — everything in one place for those who want comprehensive data: Category Marker Before After…

Agreeing with wendy_avl, and the qualification matters more than the agreement. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.

That is the short version; the long version is somebody else's post.

38 11alex_tucson, kevin_tulsa, Dr.PainCLE and 35 others
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Dr.ReproEndo
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Jan 24, 2025 at 4:54 PM#23
wendy_avl said:
Before/after bloodwork compilation for the lipid panel — everything in one place for those who want comprehensive data: Category Marker Before After…

Bookmarking. The distinction being drawn above is the one nobody else makes. Printing the relevant bit and taking it with me.

39 12Dr.EndoEP, GraceAZ_72, carl_compliance and 36 others
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Dr.EndoEP
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Jan 25, 2025 at 7:48 AM#24

Clinical perspective, offered as context rather than as advice. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

40 13Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 37 others
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Dr.LipidDallas
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Jan 25, 2025 at 10:42 PM#25
Dr.EndoEP said:
Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent…

Second this. The detail I would add is minor and it is already implied above.

Last edited: Jan 26, 2025 at 12:42 AM
41 14Dr.PulmRoch, maya_sedona, stefan_berlin and 38 others
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