Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here.

PharmacoVig_BOS said:

Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

Coming at PharmacoVig_BOS’s question from a different direction. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

Correct me if the detail matters more than I have assumed.

Adding the numbers, since they settle part of this. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Following on from PharmacoVig_BOS — and this may be the naive question:

How long did you give it before you decided it was working?

lucas_SP_BR said:

Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Pushing back on lucas_SP_BR here. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.