VendorMark said:

Practical: whatever you change, write down the date and the reason.

Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.

VendorMark said:

Practical: whatever you change, write down the date and the reason.

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Report rather than reply if it drifts again.

Adding the clinical framing, because it changes how the question reads. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

PharmHunterJen said:

Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

This matches mine closely enough to be worth saying so out loud. Posting only so the count is not one.