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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)Anyone else get super cold on tirz? I am FREEZING — 6 month update Page 4

Anyone else get super cold on tirz? I am FREEZING — 6 month update

GenomicsKate Wed, Jun 12, 2024 at 7:22 PM 17 replies 2,021 viewsPage 4 of 4
CarlaRPh_TPA
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Jun 21, 2024 at 1:12 AM#16

Clinical perspective, offered as context rather than as advice. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

28 1FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 25 others
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mike_nyc
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Jun 21, 2024 at 12:30 PM#17
raj_cambridge said:
If you are going to change something, change one thing and give it long enough to express itself.

Right, and the exception is worth naming rather than left implied, because the exception is where people get into trouble.

Happy to go further on any of that.

29 2stefan_berlin, Dr.EM_Chicago, pete_RVA and 26 others
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Dr.LeslieOBGYN
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Jun 21, 2024 at 11:48 PM#18
raj_cambridge said:
If you are going to change something, change one thing and give it long enough to express itself.

That reframing is the part I needed. Adding it to my notes with a link back to this thread.

30 3james_edin, FranDenver, Dr.BariatricHTX and 27 others
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sean_dublin
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Jun 22, 2024 at 11:05 AM#19

From the other side of the consultation, briefly. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

31 4NurseLeah_Nash, gary_naperville, sean_dublin and 28 others
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mike_mod
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Jun 22, 2024 at 10:22 PM#20

Moderator note: a couple of off-topic posts removed.

3 1PurityPaulOR, MaxMetOK, MounjBrad
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