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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)My appetite is literally gone is this normal at 10mg — November 2025 Page 3

My appetite is literally gone is this normal at 10mg — November 2025

PeptideSynthNJ Thu, May 30, 2024 at 7:10 AM 45 replies 2,266 viewsPage 3 of 9
Dr.KarenChen
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May 31, 2024 at 7:45 PM#11
DebRD_ATL said:
Rebound hunger after missed dose of food noise: I missed my injection by 3 days due to a shipping delay and the hunger came ROARING back.

Neuroscience perspective on food noise:

GLP-1 receptors are expressed throughout the CNS, with high density in the hypothalamic arcuate nucleus, area postrema, and — critically — the mesolimbic reward pathway[1].

This is directly relevant to food noise because the central effects of GLP-1 agonists extend far beyond simple appetite suppression. The reduction in "food noise" that patients describe is likely mediated by modulation of dopaminergic signaling in the VTA and nucleus accumbens.

The emerging data on reduced addictive behaviors (alcohol, gambling) further supports this mechanism. food noise should be understood in this broader neurobiological context.

References:
[1] Merchenthaler I, et al. J Comp Neurol. 1999;403(2):261-280.
Last edited: Jun 1, 2024 at 1:45 AM
16 14julia.endo, JessicaM_2024, TomFromTexas and 13 others
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FitDadDave
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Jun 1, 2024 at 12:18 AM#12
KristenIndy said:
"Food aversion" side effect of food noise that I wasn't prepared for: I used to LOVE cooking and trying new restaurants.

That reframing is the part I needed. Taking it to my next appointment.

17 15kim_atl_prep, sarah_TO, wendy_avl and 14 others
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RegAffairsDC
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Jun 1, 2024 at 4:51 AM#13
DebRD_ATL said:
Rebound hunger after missed dose of food noise: I missed my injection by 3 days due to a shipping delay and the hunger came ROARING back.

This is where I part company with the consensus forming above. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

18 16hannah_MT, Dr.SportsMedIN, amy_econ_NJ and 15 others
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josh_phd_bmore
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Jun 1, 2024 at 9:24 AM#14

One concrete data point for the thread. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

19 17KarenAZ_mom, zoe_NC, Dr.ObesityLA and 16 others
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mike_mod
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Jun 1, 2024 at 1:57 PM#15

Moderator note: a couple of off-topic posts removed. No action needed from anybody.

20 18PurityPaulOR, MaxMetOK, MounjBrad and 17 others
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