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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)Tirz + walking = the only combo I needed apparently — what worked for you?

Tirz + walking = the only combo I needed apparently — what worked for you?

mike.trainer_LA Thu, May 16, 2024 at 3:58 PM 16 replies 2,265 viewsPage 1 of 4
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mike.trainer_LA
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Apr 2024
Los Angeles, CA
May 16, 2024 at 3:58 PM#1

Training four times a week throughout and the scale has barely acknowledged it, which is demoralising in a way I did not expect.

The bit I cannot resolve on my own is what training is actually for during a large deficit, because framing it as calorie burn sets people up to quit when the arithmetic disappoints them.

Happy to be told the question itself is wrong.

36 6Dr.AddMedPHL, newstart_MO, mia_MS2 and 33 others
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Dr.GastroMayo
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Mayo Clinic, MN
May 16, 2024 at 4:08 PM#2
mike.trainer_LA said:
Training four times a week throughout and the scale has barely acknowledged it, which is demoralising in a way I did not expect.

Exercise-induced nausea amplification with training: I learned the hard way that intense exercise within 12 hours of injection can make nausea much worse. The combination of delayed gastric emptying + exercise-induced blood flow redistribution is rough on the GI system.

My workaround: inject Friday evening, do low-intensity activity Saturday, and save my intense workouts for Tuesday-Thursday when the GI effects have subsided. Timing your training around your injection schedule is a real optimization strategy.

Last edited: May 16, 2024 at 9:08 PM
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RegAffairsDC
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Washington, DC
May 16, 2024 at 4:18 PM#3
Dr.GastroMayo said:
Exercise-induced nausea amplification with training: I learned the hard way that intense exercise within 12 hours of injection can make nausea much…

Exercise transformation with training: went from barely able to walk a block to completing a 10K last weekend.

My fitness journey alongside GLP-1 therapy:

  • Month 1-2: Walking 15 min/day
  • Month 3-4: Walking 30-45 min, started bodyweight exercises
  • Month 5-6: Joined a gym, started resistance training
  • Month 7+: Running, lifting heavy, swimming for fun

The weight loss made movement possible. The movement made more weight loss possible. Virtuous cycle in action.

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Dr.DermMIA
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May 2024
Miami, FL
May 16, 2024 at 4:28 PM#4
mike.trainer_LA said:
Training four times a week throughout and the scale has barely acknowledged it, which is demoralising in a way I did not expect.

This is my experience too, for whatever a second data point is worth. The detail I would add is minor and it is already implied above.

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Dr.NephBHM_UK
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Jun 2024
Birmingham, UK
May 16, 2024 at 5:19 PM#5

Clinical perspective, offered as context rather than as advice.

Pet owner bonus of training: my dog is also losing weight because we're walking 2-3x more than before. His vet is thrilled. 🐕

We went from a 15-minute shuffle around the block to 60-minute walks through the neighborhood. He's more energetic, I'm more energetic, and we're both healthier.

Get a dog. Or borrow one. Walking a dog is the best low-impact exercise motivation that exists. They never let you skip a walk. 🐾

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