VanRx_Mike said:Freezing is the one to avoid, and freeze-thaw more so.
All true, with one condition: that curve is for people who reached the dose on schedule. Anyone who slowed the ladder for tolerability is on a different, flatter curve, and comparing yourself with the published mean will make you feel like a non-responder when you are not.
Dr.NateNeph said:The dose-response is real but shallow at the top.
This is exactly what I could not find anywhere else.
VanRx_Mike said:Freezing is the one to avoid, and freeze-thaw more so.
Pushing back on VanRx_Mike here. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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