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ForumsSemaglutide (Ozempic / Wegovy)STEP 1-5 trials comprehensive summary — efficacy endpoints compiled Page 2

STEP 1-5 trials comprehensive summary — efficacy endpoints compiled

TrialTracker_MD Mon, Jun 8, 2026 at 11:39 AM 12 replies 288 viewsPage 2 of 3
Dr.NateNeph
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Jun 8, 2026 at 12:46 PM#6

One concrete data point for the thread. For anyone assembling their own picture: Tmax is one to three days, terminal half-life about 165 to 170 hours, steady state at four to five weeks, and subcutaneous bioavailability near 89%. Those four numbers explain most of the questions people ask about timing.

Last edited: Jun 8, 2026 at 2:46 PM
29 24JakeSmashed95, NauseaFreeNow, SteveThurs and 26 others
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tampaLisa73
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Jun 8, 2026 at 1:12 PM#7

A narrower follow-up, since the general answer is now clear:

Whether anyone has held at a sub-maximal dose long term and kept the result, or whether the maintenance data only exists at 2.4mg?

Last edited: Jun 8, 2026 at 2:12 PM
28 23FitDadDave, RunnerRach, TrialNerd_Beth and 25 others
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Dr.LipidDallas
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Jun 8, 2026 at 1:37 PM#8
Dr.NateNeph said:
For anyone assembling their own picture: Tmax is one to three days, terminal half-life about 165 to 170 hours, steady state at four to five weeks, and…

There is a second half to this that has not been said yet. The dose-response is real but shallow at the top. Across STEP 1 and STEP 4 the gap between 1.7mg and 2.4mg is a couple of percentage points of body weight on average, and the average is carrying a wide spread — plenty of people at 1.7mg sit above the 2.4mg mean. If a dose is working and tolerable, "working" is the relevant variable, not "maximal".

Last edited: Jun 8, 2026 at 3:37 PM
27 22cory_ATX, lori_vegas, Dr.PulmRoch and 24 others
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TrialTracker_MD
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Jun 8, 2026 at 2:03 PM#9

Closing the loop on my own question.

Six weeks on from posting: I stopped reading the weekly number and started reading a four-week average, and the "stall" I opened this thread about was a 1.8kg loss I could not see.

Last edited: Jun 8, 2026 at 7:03 PM
26 21Dr.PulmRoch, maya_sedona, stefan_berlin and 23 others
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jason_sac26
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Jun 8, 2026 at 4:07 PM#10
Dr.LipidDallas said:
The dose-response is real but shallow at the top.

Agreeing with Dr.LipidDallas, and the qualification matters more than the agreement. Steady state is the thing most people miss. The terminal half-life is about a week, so every dose step takes four to five weeks to fully express itself. Judging a step at day ten is judging the ascent, not the plateau, and it is the single commonest reason people escalate before they needed to.

Worth separating that from the trial evidence, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

46 19Dr.PulmRoch, maya_sedona, stefan_berlin and 43 others
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