Dr.BariatricHTX said:

Worth answering the question that was asked rather than the one behind it.

Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.

raj_cambridge said:

The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

This is exactly what I could not find anywhere else. Sending this to two other people who asked me the same thing last week.

From the other side of the consultation, briefly. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

jim_asheville said:

The distinction that resolves most of these threads is between what is true on average and what is true for one person.

That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Thread quality here is what the rules are for. Keep it up.