Dr.SportsMedIN said:The useful move here is to separate what is established from what is widely repeated.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
nick_newbie said:The dose-response is real but shallow at the top.
That reframing is the part I needed.
Dr.SportsMedIN said:The useful move here is to separate what is established from what is widely repeated.
Pushing back on Dr.SportsMedIN here. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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Shop Reference StandardsAdding the numbers, since they settle part of this. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.
Correct me if the detail matters more than I have assumed.
Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Tagging this one for the weekly digest.