Clinical perspective, offered as context rather than as advice. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.
Dr.SurgeonPGH said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. The counter-case has not been addressed. Somebody upthread described the situation that does not fit, and the thread moved on rather than engaging with it, which is the failure mode this board is supposed to avoid.
Dr.SurgeonPGH said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.
Sigma-Aldrich — Research-Grade Standards
Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.
Shop Reference StandardsDr.SurgeonPGH said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
Thank you for spelling out the reasoning rather than just the conclusion. I will report back once I have actually tried it.