🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsSemaglutide (Ozempic / Wegovy)Why does sema make me SO tired??

Why does sema make me SO tired??

SleepFixSam Wed, Apr 1, 2026 at 10:34 AM 14 replies 900 viewsPage 1 of 3
SleepFixSam
Member
212
678
Nov 2024
Hawaii
Apr 1, 2026 at 10:34 AM#1

The fatigue arrived at about week six and has not shifted since, and I cannot tell whether it is the drug, the deficit or something I should have tested by now.

What would genuinely help is knowing whether the fatigue is a direct drug effect or simply the caloric deficit, because the answer changes what you do about it.

I have searched first, so if this is covered somewhere point me at it and I will read it.

21 16pete_nash, hank_denver, carlos_SATX and 18 others
Reply Quote Save Share Report
Dr.SportsMedIN
Senior Member
1,456
6,789
Feb 2024
Indianapolis, IN
Apr 1, 2026 at 10:40 AM#2

Short answer first, then the reasoning. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.

20 15lisa_labSD, adam_van, Dr.SurgeonPGH and 17 others
Reply Quote Save Share Report
TomTeleRx
Member
189
678
Feb 2025
Delaware
Apr 1, 2026 at 10:46 AM#3
Dr.SportsMedIN said:
Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent…

Right, and the exception is worth naming rather than left implied, because the exception is where people get into trouble.

19 14LibrarianMeg, bri_stats, pete_manc_UK and 16 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
jason_sac26
New Member
34
123
Jan 2026
Sacramento, CA
Apr 1, 2026 at 10:52 AM#4
SleepFixSam said:
The fatigue arrived at about week six and has not shifted since, and I cannot tell whether it is the drug, the deficit or something I should have…

Mine went the same way, slower. Nothing to add that would improve it.

Last edited: Apr 1, 2026 at 12:52 PM
18 13maya_sedona, stefan_berlin, Dr.EM_Chicago and 15 others
Reply Quote Save Share Report
lisa_labSD
Member
278
1,234
Oct 2024
San Diego, CA
Apr 1, 2026 at 11:20 AM#5

Adding the clinical framing, because it changes how the question reads. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

Last edited: Apr 1, 2026 at 2:20 PM
17 12cory_ATX, lori_vegas, Dr.PulmRoch and 14 others
Reply Quote Save Share Report

Similar Threads

STEP 1-5 trials comprehensive summary — efficacy endpoints compiled12 replies
Oral semaglutide 50mg Phase 3 — OASIS program results16 replies
Semaglutide pharmacokinetics — half-life, Tmax, steady state modeling10 replies
Compounded semaglutide stability data — temperature and light sensitivity16 replies
0.25mg → 2.4mg titration: optimal schedule based on clinical data6 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register