PharmD_Rodriguez said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.
HPLC_Greg said:The mechanism is more central than most summaries suggest.
This answered a question I did not know how to ask.
PharmD_Rodriguez said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.
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Shop Reference StandardsAdding the numbers, since they settle part of this. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.
Moderator note: the sourcing question belongs in the vendor section and has been split out. Thread quality here is what the rules are for. Keep it up.