AttorneyGrant said:

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

This matches mine closely enough to be worth saying so out loud.

AttorneyGrant said:

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

Adding the part of the answer the thread has not reached. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

One concrete data point for the thread. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

Correct me if the detail matters more than I have assumed.

One thing that is still open after AttorneyGrant’s answer:

What did you change at the same time, and can you separate the two now?

lisa_labSD said:

If you are going to change something, change one thing and give it long enough to express itself.

This is where I part company with the consensus forming above. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.