labquiet_amy said:The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…
Thank you for spelling out the reasoning rather than just the conclusion.
Clinical perspective, offered as context rather than as advice. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.
LibrarianMeg said:It helps to ask what evidence would change your mind before you look at any.
Second this. The detail I would add is minor and it is already implied above.
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Shop Reference StandardsLibrarianMeg said:It helps to ask what evidence would change your mind before you look at any.
Coming at LibrarianMeg’s question from a different direction. The mechanism that matters here is not stomach emptying, it is central. GLP-1 receptor agonism in the arcuate nucleus stimulates POMC neurons and suppresses AgRP/NPY signalling, which is why the effect is appetite and food salience rather than physical fullness. Delayed gastric emptying largely tachyphylaxes over the first months; the appetite effect does not.
The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.